This study investigated the effect of pre-marriage guidance and counseling model according to multiple aspects domestic approach on marital satisfaction. Methodology: Statistical society includes couples who came to the health centers of Tabriz and were selected based on convenience sampling. (Twelve couples in experimental group and 12 couples in control group). This research is quasi-experimental design. ENRICH marital satisfaction questionnaire was used via post-test and per-test methods. To analyze the data, Covariance analysis was applied. The findings of the study indicated that pre-marriage guidance and counseling model according to multiple aspects domestic approach has improved marital satisfaction, personality aspects, relationships, conflict- solving, financial matters, free time, relationship with family and friends, coupling roles, and religion spiritual orientations. This impact was significant but the impact of this model on sexual relationship and offspring education was not significant. Conclusion, According to the interactional and complex relationships between personal, marital and cultural – social issues, we can use pre-marriage guidance and counseling model based on multiple aspects domestic approach to increase marital satisfaction.